General facts about Priligy
Priligy is one of the safest male enhancement products that we have. Its main ingredient is called Dapoxetine, a chemical that works to inhibit serotonin transporter and enhance serotonin action. If you are eighteen to twenty-four years old and you need treatment for premature ejaculation (PE), this is the best medicine to use. Priligy is guaranteed to delay ejaculation.
Beginnings of the Drug
The main ingredient of this product was originally produced by the pharmaceutical company Eli Lilly. In 2003, Eli Lilly sold the rights to Johnson & Johnson back in 2003. In 2004, Johnson & Johnson gained the approval of the Food and Drug Administration to sell Dapoxetine for treating PE. Priligy is not only sold in the US. It is also a fast-selling male enhancement product in Asian countries, European countries and in Mexico.
Very Minimal Side Effects
One good thing about this drug is its ability to be absorbed and eliminated outside of the body quickly. This ability makes the drug a very suitable treatment for PE. This good pharmacokinetics prevents the accumulation of the drug in the blood in large doses. Therefore, there are very minimal side effects associated with this drug. According to research, less than 1% of users have experienced libido loss and less than 4% reported having bouts with erectile dysfunction. Another thing to note: No cases of drug overdose has been reported with clinical trials.
No Reactions with Other Substances
Priligy is capable of resisting reactions with other substances. If you are taking other male enhancing products, this drug will not cause undue synergism. It has been determined that Priligy does not react with Sildenafil and Taladafil. Ethanol is another substance with which this drug does not react.
According to research, no food reacts significantly with this drug. Even high fat meals don’t have significant effects. Therefore, this drug can be taken orally whether the stomach is empty or not.
Mechanism of Priligy Actions
This drug works directly with the central nervous system which is the regulator of human ejaculation. As mentioned, the drug inhibits serotonin transporter and increase serotonin action. It is still unclear how these actions affect the ejaculatory processes. What is known to scientist is the pathway of ejaculation and this is how it happens every time: Stimuli from the human male genital excite the spinal cord somewhere at the lumbosacral and thoracolumbar levels. This nervous message is then relayed to the brain stem. One study found that this drug controls the reflex for ejaculatory expulsion by regulating the activity of the lateral paragigantocellular nucleus neurons.
Absorption and Excretion
Priligy’s main ingredient is soluble in water. This substance is white and is in the form of powder. The recommended time to take the drug is one to three before sex. One to two hours after administration, the drug is able to reach its highest level of concentration in the plasma. And once taken, the drug is rapidly distributed with around 99% of Dapoxetine found in the plasma.
The Dapoxetine metabolites are rapidly excreted through urine. The half-life, calculated after urinary excretion, for the 30-mg and 60 mg doses respectively are 18.7 and 21.9 hours.